Mangul Lab submits preprint of a WGS-based structural variant callers benchmarking study

Mangul Lab at USC shared a new preprint which presents a benchmarking study of structural variant (SV) callers – computational tools for identifying genomic regions that have altered DNA and may be implicated in various diseases and disorders. Varuni Sarwal, alumnus of Serghei’s group at UCLA, is the first [...]

Mangul Lab pens commentary piece on conference travel for junior scientists in the wake of climate change

Mangul Lab at USC shared a new preprint of 2020 which presents a conversational editorial on the difficult choices that junior scholars face when choosing to travel via airplane to scientific conferences. With the ever-increasing carbon footprint associated with conferences, scientists can learn to refine their conference experiences when [...]

By |2020-04-21T17:41:39+00:00April 13th, 2020|Categories: Commentary, Preprints|Tags: , , |

Mangul Lab submits preprint presenting recommendations to enhance rigor and reproducibility in biomedical research

Mangul Lab at USC has shared a new preprint, which presents our group’s review of efforts to improve scientific rigor and reproducibility via open-source data and academic software. Computational methods have reshaped the landscape of modern biology. While the biomedical community is increasingly dependent on computational tools, the mechanisms [...]

By |2020-04-21T17:41:12+00:00March 30th, 2020|Categories: Commentary, Preprints|Tags: , , |

Mangul Lab submits preprint presenting Metalign, software that boosts accuracy of existing metagenomic profiling methods

Mangul Lab at USC shared a new preprint which presents Metalign - a tool developed by our group that significantly improves the taxonomic profiling accuracy of a metagenomic sample. Overview of Metalign Microorganisms play a critical role in almost every natural setting, including soil, ocean water, and [...]

Mangul Lab submits preprint exploring read alignment techniques for short and long reads

Last week, Mangul Lab at USC shared a new preprint, which presents our group’s review of the role algorithms have on speed and efficiency of read aligners. Overview of read alignment Modern sequencing platforms generate enormous amounts of genomic data in the form of nucleotide sequences or [...]

Mangul Lab submits preprint presenting a comprehensive review of the diagnostic and therapeutic potential of metagenomics

Just before the Thanksgiving holiday break, Mangul Lab at USC released our second preprint—a review of the diagnostic and therapeutic potential of metagenomics. Overview of clinical metagenomics pipeline Several members of our group—Caitlin Loeffler (Bioinformatics Analyst), Lana Martin (Project Specialist), Yutong Chang (Master’s student), Jeremy Rotman (alumni)—collaborated with [...]

Mangul Lab submits first preprint presenting app for managing high-throughput analyses via mobile device

This week, Mangul Lab at USC released our first preprint, a paper that presents Telescope - a tool developed by our group for management of cloud-based high-throughput analyses! In today’s world of big data, high-performance computational facilities are capable of processing considerable volumes of data. Computational resources capable of analyzing [...]